| MD | Slime World | 1993 | Action |
| MD | Snake Rattle 'n' Roll | 1993 | Plateforme |
| MD | Snow Bros. Nick & Tom | 1993 | Arcade |
| MD | Socket | 1993 | Jeu de plateau |
| MD | Sol-Deace | 1992 | Shoot-em-up |
| MD | Sonic & Knuckles | 1994 | Plateforme |
| MD | Sonic 3D Flickies' Island | 1996 | Plateforme |
| MD | Sonic Compilation | 1995 | Compilation |
| MD | Sonic Eraser | 1991 | Puzzle |
| MD | Sonic the Hedgehog | 1991 | Plateforme |
| MD | Sonic the Hedgehog 2 | 1992 | Plateforme |
| MD | Sonic the Hedgehog 3 | 1993 | Plateforme |
| MD | Sonic the Hedgehog Spinball | 1993 | Jeu électromécanique |
| MD | Sorcerer's Kingdom | 1992 | RPG |
| MD | Sorcerian | 1990 | RPG |
| MD | Space Harrier II | 1989 | Shoot-em-up |
| MD | Space Invaders 90 | 1990 | Shoot-em-up |
| MD | Sparkster: Rocket Knight Adventures 2 | 1994 | Plateforme |
| MD | Speedball 2 | 1992 | Sport |
| MD | Spider-Man | 1991 | Plateforme |
| MD | Spider-Man & Venom: Maximum Carnage | 1994 | Beat-em-all |
| MD | Spider-Man : The Animated Series | 1995 | Plateforme |
| MD | Spider-Man and the X-Men: Arcade's Revenge | 1993 | Plateforme |
| MD | Spiritual Warfare | 1994 | Action, Aventure |