| MD | Scholastic's The Magic School Bus: Space Exploration Game | 1995 | Educatif |
| MD | Scooby-Doo Mystery | 1995 | Aventure, Point-n-click |
| MD | SeaQuest DSV | 1994 | Action |
| MD | Second Samurai | 1994 | Action, Plateforme |
| MD | Sensible Soccer: European Champions | 1993 | Sport |
| MD | Sesame Street Counting Cafe | 1994 | Educatif |
| MD | Shadow Blasters | 1990 | Action, Plateforme |
| MD | Shadow Dancer : The Secret of Shinobi | 1991 | Action, Plateforme |
| MD | Shadow of the Beast | 1991 | Action, Plateforme |
| MD | Shadow of the Beast II | 1992 | Action, Plateforme |
| MD | Shadowrun | 1994 | RPG |
| MD | Shanghai II: Dragon's Eye | 1994 | Jeu de plateau |
| MD | Shaq Fu | 1994 | Versus fighting |
| MD | Shining Force | 1993 | RPG |
| MD | Shining Force II | 1994 | RPG |
| MD | Shining in the Darkness | 1991 | RPG |
| MD | Shinobi III: Return of the Ninja Master | 1993 | Action, Plateforme |
| MD | Shogi no Hoshi | 1991 | Jeu de plateau |
| MD | Shove it!… The Warehouse Game | 1990 | Puzzle |
| MD | Shura no Mon | 1992 | RPG, Sport |
| MD | Side Pocket | 1992 | Sport |
| MD | Skeleton Krew | 1995 | Action |
| MD | Skitchin' | 1994 | Course |
| MD | Slap Fight MD | 1993 | Shoot-em-up |