| MD | Dragon: The Bruce Lee Story | 1994 | Versus fighting |
| MD | Duke Nukem 3D | 1998 | Tir |
| MD | Dune II : la Bataille d\'Arrakis | 1993 | Stratégie temps réel |
| MD | Dungeons & Dragons: Warriors of the Eternal Sun | 1992 | RPG |
| MD | Dyna Brothers | 1992 | etc. |
| MD | Dyna Brothers 2 | 1993 | etc. |
| MD | Dynamite Duke Seibu | 1989 | Rail shooter |
| MD | Dynamite Headdy | 1994 | Plateforme |
| MD | Earnest Evans | 1992 | Action, Plateforme |
| MD | Earth Defense [US] | 1995 | Shoot-em-up |
| MD | Earthworm Jim | 1994 | Plateforme |
| MD | Earthworm Jim 2 | 1995 | Plateforme |
| MD | Ecco 2 : les Marées du Temps | 1994 | Action, Aventure |
| MD | Ecco Jr. | 1995 | Action, Aventure |
| MD | Ecco the Dolphin | 1992 | Action, Aventure |
| MD | El Viento | 1991 | Action, Plateforme |
| MD | Elemental Master | 1990 | Shoot-em-up |
| MD | Eliminate Down | 1993 | Shoot-em-up |
| MD | Empire of Steel | 1993 | Shoot-em-up |
| MD | ESPN Baseball Tonight | 1995 | Sport |
| MD | ESPN National Hockey Night | 1994 | Sport |
| MD | ESPN Speed World | 1994 | Course |
| MD | ESPN Sunday Night NFL | 1994 | Sport |
| MD | ESWAT : City Under Siege | 1990 | Action, Plateforme |